J. Pharm. Technol. Res. Manag.

Ebola Hemorrhagic Fever: Recent Update On Disease Status, Current Therapies And Advances In Treatment

Jaskaran Singh, Thapa Komal, Sandeep Arora, Amarjot Kaur and Thakur Gurjeet Singh


Filovirus; Ebola; Single-stranded ribonucleic acid; GRADE; vaccines; rVSV-EBOV; Favipiravir; ZMapp.

PUBLISHED DATE November 2017
PUBLISHER The Author(s) 2017. This article is published with open access at www.chitkara.edu.in/publications

Swiftly growing viruses are a major intimidation to human health. Such viruses are extremely pathogenic like Ebola virus, influenza virus, HIV virus, Zika virus etc . Ebola virus, a type of Filovirus, is an extremely infectious, single-stranded ribonucleic acid virus that infects both humans and apes, prompting acute fever with hemorrhagic syndrome. The high infectivity, severity and mortality of Ebola has plagued the world for the past fifty years with its first outbreak in 1976 in Marburg, Germany, and Frankfurt along with Belgrade and Serbia. The world has perceived about 28,000 cases and over 11,000 losses. The high lethality of Ebola makes it a candidate for use in bioterrorism thereby arising more concern. New guidelines have been framed for providing best possible care to the patients suffering from Ebola virus i.e Grading of Recommendation Assessment, Development And Evaluation (GRADE) methodology to develop evidence-based strategy for the treatment in future outbreak of Ebola virus. No drugs have been approved, while many potent drugs like rVSV-EBOV, Favipiravir, ZMapp are on clinical test for human safety. In this review we will discover and discuss perspective aspects that lead to the evolution of different Ebola variants as well as advances in various drugs and vaccines for treatment of the disease.

Page(s) 217–234
URL http://dspace.chitkara.edu.in/jspui/bitstream/123456789/670/1/JPTRM%205-2-6.pdf
ISSN Print : 2321-2217, Online : 2321-2225
DOI 10.15415/jptrm.2017.52013
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