An Update on Some Recent Solubility Enhancers as Pharmaceutical Excipients

Vivek Puri, Pratima Sharma and Manju Nagpal

  • Download PDF
  • DOI Number

Soluplus, captisol, gum, polymer, biodegradable, synthetic


At present the pharmaceutical academia and industries are focusing on the use of natural materials and resources for development of pharmaceutical product. Due to advances in drug delivery technology, currently, excipients are included in novel dosage forms to fulfill specific functions. Various natural polymers are widely being studied as a potential carrier material for site specific drug delivery because of its non-toxic and biocompatible in nature. Natural polymers (polysaccharides) have been investigated for drug delivery applications as well as in biomedical fields. Modified polymer or synthetic polymers have found its application as a support material for cell culture, tissue engineering and gene delivery. Recent trends towards use of natural products or plant based products demand the replacement of synthetic additives with natural ones. These natural materials have many advantages over synthetic ones as they are biodegradable, chemically inert, less expensive, nontoxic and widely available. This review provides an overview of the different modified polymer derivatives and their applications with special consideration being put on biomedical engineering and controlled drug delivery.

  • Abayomi, T., Ogunjimi and Gbenga, A. (2014). Material and Tableting Properties of Azadirachta Indica Gum With Reference to Official Acacia Gum. Acta Poloniae Pharmaceutica - Drug Research,71, 107–118.
  • Abayomi, T.O., Gbenga, A. (2014). Neem Gum as a Binder in a Formulated Paracetamol Tablet with Reference to Acacia Gum BP. AAPS Pharm SciTech, 10(5), 500–510.
  • Alireza, H., Fatemeh, S., Ali, N., Jaleh, V., Hadi, A.G. (2015). Preparation and Characterization of Celecoxib Dispersions in Soluplus: Comparison of Spray Drying and Conventional Methods. Iranian Journal of Pharmaceutical Research, 14(1), 35–50.
  • Alireza, H., Fatemeh, S., Jaleh, V., Hadi, A. G., Ali, N. (2015). Preparation and Characterization of Celecoxib Dispersions in Soluplus: Comparison of Spray Drying and Conventional Methods. Iranian Journal of Pharmaceutical Research, 1–20.
  • Balambhaigari, R.Y., Yalavarthi, P.R., Vulava, J., Vadlamudi, H.C., Nair, R. (2012). Design and Assessment of Colon Specific Drug Delivery of Mefenamic Acid Using Modified Pulsincaps Technique and Hupu Gum. Indo American Journal of Pharmaceutical Research, 2(9),1026–1038.
  • Chavan, S., Patel, K., Shelar, D., Vavia, P. (2013). Preparation of Oxcarbazepine Solid Dispersion by Hot Melt Extrusion for Enhanced Dissolution: Downstream Processing to Tablets. American Journal of Pharmtech Research, 3(1), 557–569.
  • Choudhary, P.D., Harshal, A.P. (2014). Recently Investigated Natural Gums and Mucilages as Pharmaceutical Excipients: An Overview. Journal of Pharmaceutics, 1–9.
  • Ha, E.S., Baek, I.H., Cho, W., Hwang, S.J., Kim, M.S. (2014). Preparation and Evaluation of Solid Dispersion of Atorvastatin Calcium with Soluplus by Spray Drying Technique. Chemical & Pharmaceutical Bulletin, 62(6), 545–551.
  • Homayouni, A., Sadeghi, F., Varshosaz, J., Garekani, H. (2012).Soluplus-A Novel Excipient to Improve Dissolution Rate of Poorly Water Soluble Drug, Celecoxib. Research in Pharmaceutical Sciences, 7(5), S386.
  • Jain, A.K.S., Date, A.A., Pissurlenkar, R.S.S., Coutinho, E.C., Nagarsenker, M.S. (2011). Sulfobutyl Ether7 Β-Cyclodextrin (Sbe7 Β-Cd) Carbamazepine Complex: Preparation, Characterization, Molecular Modeling, and Evaluation of in Vivo Anti-Epileptic Activity. AAPS Pharm SciTech, 12, 1163–1175.
  • Jana, S., Gandh, A., Sen K.K., Basu, S.K.(2011). Natural Polymer and their application in Drug Delivery and Biomedical Field. Journal of Pharmacy Science Technology 1(1), 16–27.
  • Janipalli, A.P., Duppala, L., Mylangam, C.K., Sirisolla, J.D., Kolapalli, V.R.M. (2015). Assessment of Hupu Gum for its Mucoadhesive Property in the Design and Evaluation of Mucoadhesive Buccal Patches of Propranolol HCl. International Journal of Pharm Research & Review, 4(9), 9–20.
  • Jia, L., Feng, C., Can, Z., Qineng, P. (2013). Use of Polymer Combination in the Preparation of Solid Dispersions of a Thermally Unstable Drug by Hot-Melt Extrusion. Acta Pharmaceutica Sinica, B3(4), 63–272.
  • Jinwen, L., Meijuan, Z., Hongyu, P., Yi, Liu., Bo, T., Ying, G., et al. (2015). Characterization and Pharmacokinetic Study of Aprepitant Solid Dispersions with Soluplus. Molecules, 20, 11345–11356.
  • Kulkarni, A.P., Yunus R.S., Dehghan, M.H.D., (2013). Application of Neem Gum for Aqueous Film Coating of Ciprofloxacin Tablets. International Journal of Applied Research in Natural Products, 6(3), 11–19.
  • Mendiratta, C., Kadam, V., Pokharkar, V. (2011). Lansoprazole Solid Dispersion Using a Novel Amphillic Polymer Soluplus. Journal of Chemical and Pharmaceutical Research, 3(6), 536-543.
  • More, S.D., Sontakke, S.B. (2013). Solubility Enhancement of Gliclazide by Solid Dispersion Method. Asian Journal of Pharmaceutical and Clinical Research, 6,91–98.
  • Nawaz, M., and Gowda, D.V (2014). Formulation and Evaluation of Mango Gum Microspheres as a Targeted Drug Delivery to Colon. International Journal of Pharma and Bio Sciences, 5(4), 126-137.
  • Nayak, A., Nayak, R.N., Bhatt, K., Kudalkar, M., Soumya, B. (2011). Evaluation of antibacterial and anticandidal efficacy of aqueous and alcoholic extract of neem(A. indica). An in vitro study. International Journal of Research in Ayurveda and Pharmacy, 2(1), 230–235.
  • Reddy, B., Madhusudhan, A., Dadigala, R., Kotu, G.M., Guttena, V. (2013). Development, Evaluation and Characterization of Surface Solid Dispersion for Solubility and Dispersion Enhancement of Irbesartan. Journal of Pharmacy Research, 7, 472–477.
  • Rodde, M.S., Divase, G.T., Devkar, T.B., Tekade, A.R. (2014). Solubility and Bioavailability Enhancement of Poorly Aqueous Soluble Atorvastatin: In Vitro, Ex Vivo, and in Vivo Studies. BioMed Research International Volume, 1–10.
  • Sambath, L., Muthu, K. A., Kumar, M. A., Phaneendra, K., Shalini. (2013). Physicochemical Characterization and In-Vitro Dissolution Behavior of Gliclazide-Soluplus Solid Dispersions. International Journal of Pharmacy and Pharmaceutical Sciences, 5, 204–210.
  • Sharma, P., Tomar, L., Bachwani, M., Bansal, V. (2011). Review on Neem Gum (Azadirachta indica):Thousands Problems One Solution. International Research Journal of Pharmacy, 2(12), 97–102.
  • Shejul, A., Deshmane, S, Biyani, K. (2014). Modified Natural Carrier in Solid Dispersion for Enhancement of Solubility of Poorly Water Soluble Drugs. Journal of Drug Delivery & Therapeutics, 4(1), 111–116.
  • Shejul, A., Deshmane, S., Biyani, K. (2014). Modification and Physical Characterization of Hupu Gum as a Carrier in Solid Dispersion Containing Clopidogrel Bisulphate. American Journal of Pharmtech and Health Research, 2, 2321–3647.
  • Shingne, N. S., Nagpure, S.V., Deshmane, S. V., Biyani, K. R. (2013). Modified Hupu Gum: A Novel Application in Solid Dispersion Containing Pioglitazone HCl. American Journal of Pharmtech Research 3(4), 2249–3387.
  • Singh, A.K., Selvam, R.P., Sivakumar, T. (2010). Isolation, characterization and formulation properties of a new plant gum obtained from mangifera indica. International Journal of Pharmaceutical and Biomedical Research, 1(2), 35–41.
  • Singh, A.K., Shingala, V.K., Selvam, R.P., Sivakumar, T. (2010). Evaluation of mangifera indica gum as tablet Binder. International Journal of Pharmtech Research Coden, (II), 2098–2100.
  • Urve, P., Ingrid, T., Ivo, L., Andres, L., Kalle, K., Peep, V., et al. (2014). Soluplus Graft Copolymer: Potential Novel Carrier Polymer in Electro spinning of Nano fibrous Drug Delivery System for Wound Therapy. Biomed Research International, 1–7.
  • Yano, H., Kleinebudde, P. (2010). Improvement of Dissolution Behavior for Poorly Water- Soluble Drug by Application of Cyclodextrin in Extrusion Process: Comparison between Melt Extrusion and Wet Extrusion. AAPS Pharm SciTech, 11, 885–893.